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Multiple Organ Phenotype of Fatigue
Xiaohua Liu1, Zhonghan Zhao1, Yuan Zhang2
1School of Exercise and Health, Shanghai University of Sport, Shanghai 200438, China.
Biomolecules
|October 29, 2025
Summary
This study categorizes fatigue into sports, occupational, and pathological types. It explores fatigue mechanisms across multiple body systems, offering targets for gene-assisted therapies and improved clinical management.
Area of Science:
- Physiology
- Pathology
- Genetics
Background:
- Fatigue is a common subjective experience and a complex physiological and pathological state.
- Current definitions and classifications of fatigue lack consensus.
- Fatigue affects multiple organs and systems within the body.
Purpose of the Study:
- To categorize fatigue based on its causes: sports, occupational, and pathological fatigue.
- To elaborate on the manifestations and mechanisms of fatigue across various physiological systems.
- To uncover intrinsic connections between fatigue phenotypes in different systems.
Main Methods:
- Classification of fatigue into sports, occupational, and pathological fatigue.
- Detailed elaboration on fatigue manifestations and mechanisms.
- System-level analysis of fatigue phenotypes across motor, nervous, cardiovascular, digestive, urinary, endocrine, and reproductive systems.
Main Results:
- Categorization of fatigue into three distinct types based on etiology.
- Comprehensive description of fatigue's impact on key physiological systems.
- Identification of cross-system connections in fatigue presentation.
Conclusions:
- The findings provide a framework for understanding fatigue across different contexts.
- Key targets for gene-assisted therapy of fatigue-related complications are suggested.
- Establishes a new theoretical foundation for fatigue management and research.
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