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Related Concept Videos

Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
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Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers
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Promoting Re-Epithelialization in Diabetic Foot Wounds Using Integrative Therapeutic Approaches.

Lucia Bubulac1, Iuliana-Raluca Gheorghe2, Elisabeth Ungureanu3

  • 1Department of Family Medicine, Faculty of Medicine, "Carol Davila" University of Medicine and Pharmacy, 020021 Bucharest, Romania.

Bioengineering (Basel, Switzerland)
|October 29, 2025
PubMed
Summary
This summary is machine-generated.

An Integrative Therapeutic Protocol significantly improved diabetic wound healing and glycemic control compared to standard ozone therapy alone. This approach offers a promising new avenue for managing chronic diabetic ulcers.

Keywords:
chronic woundsdiabetic foot woundsgut microbiomeintegrative medicinelow-frequency electromagnetic therapyoxidative stressozone therapyre-epithelializationwound healing

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Area of Science:

  • Endocrinology
  • Dermatology
  • Regenerative Medicine

Background:

  • Diabetes mellitus is a global health challenge with high prevalence in Romania.
  • Diabetic patients frequently develop chronic skin ulcers, impacting quality of life and increasing complication risks.
  • Effective management of diabetic foot ulcers remains a critical clinical need.

Purpose of the Study:

  • To evaluate the efficacy of an Integrative Therapeutic Protocol in healing chronic diabetic ulcers.
  • To compare the protocol's effectiveness against standard therapy including ozone therapy.
  • To assess the protocol's impact on glycemic control and inflammatory markers.

Main Methods:

  • A prospective study involving 28 patients with type I or II diabetes and chronic foot/calf ulcers (>4 cm²).
  • Intervention group received Integrative Therapeutic Protocol: ozone therapy, pulsed electromagnetic field therapy (PEMF), colon hydrotherapy with probiotics, and an alkaline diet.
  • Control group received standard therapy including ozone therapy.

Main Results:

  • The intervention group showed significantly higher re-epithelialization (86.2%) compared to controls (58.2%) after 8 weeks (p < 0.01).
  • Significant improvements were observed in the intervention group for blood glucose (-38%), HbA1c (-25%), CRP (-26%), and fibrinogen (-28%) versus baseline.
  • The Integrative Therapeutic Protocol demonstrated statistically significant advantages over standard ozone therapy for all measured endpoints.

Conclusions:

  • The Integrative Therapeutic Protocol effectively accelerates wound healing in diabetic patients with chronic ulcers.
  • This comprehensive approach also improves glycemic control and reduces key inflammatory biomarkers.
  • Further research is needed to clarify the specific contribution of dietary components like the alkaline diet.