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Sagittal Plane Kinematic Gait Analysis in C57BL/6 Mice Subjected to MOG35-55 Induced Experimental Autoimmune Encephalomyelitis
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Joint Kinematics and Gait Pattern in Multiple Sclerosis: A 3D Analysis Comparative Approach.

Radu Rosulescu1,2, Mihnea Ion Marin3, Elena Albu4

  • 1Department of Pathophysiology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.

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|October 29, 2025
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Summary
This summary is machine-generated.

People with multiple sclerosis (MS) exhibit altered lower limb (LL) movement control, with the ankle most affected. Gait analysis reveals impaired motor control rather than structural joint issues.

Keywords:
3D motion analysisgaitjoint kinematicmultiple sclerosis

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Area of Science:

  • Neurology
  • Biomechanics
  • Movement Science

Background:

  • Multiple sclerosis (MS) is a neurodegenerative disease impacting motor function.
  • Gait asymmetry and altered joint kinematics are common in people with MS (pwMS).

Purpose of the Study:

  • To compare lower limb (LL) behavior, gait asymmetry, and joint kinematics between pwMS and healthy controls.
  • To identify specific joint involvement and gait phases affected by MS.

Main Methods:

  • Cross-sectional study involving 15 pwMS (EDSS ≤ 4.5) and 15 healthy controls.
  • VICON Motion Capture System used to collect kinematic data over five gait cycles.
  • Analysis of lower limb joints' range of motion (ROM) and movement symmetry.

Main Results:

  • The ankle was the most affected joint in pwMS, followed by the knee, while the hip showed no significant differences.
  • The swing phase demonstrated greater left-right asymmetry (higher RMSE) compared to the stance phase.
  • No significant left-right joint asymmetry was observed during the complete gait cycle in pwMS.

Conclusions:

  • MS primarily affects motor control, impairing fine-tuning between joints, rather than causing structural joint damage.
  • Global motor control dysfunction, rather than isolated joint asymmetry, characterizes gait impairment in MS.