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Beyond Single Systems: How Multi-Agent AI Is Reshaping Ethics in Radiology.
Sara Salehi1, Yashbir Singh2, Parnian Habibi2
1Radiology Informatics Lab, Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA.
Bioengineering (Basel, Switzerland)
|October 29, 2025
Summary
Advanced multi-agent AI in radiology enhances diagnostics and efficiency but deepens the "black box" problem. New methods are needed to address compound opacity and maintain trust in AI systems.
Area of Science:
- Artificial Intelligence in Medical Imaging
- Radiology Workflow Optimization
- Explainable AI (XAI)
Background:
- Radiology is shifting towards complex multi-agent AI systems for autonomous reasoning and workflow management.
- These systems extend beyond basic pattern recognition to handle intricate tasks like image analysis, report generation, and care coordination.
- While promising benefits, these advanced AI systems exacerbate the 'black box' problem, challenging traditional explainability methods.
Purpose of the Study:
- To examine the 'compound opacity' issue arising from multi-agent AI interactions in radiology.
- To analyze the autonomy-transparency paradox in radiological AI, where increased capability conflicts with interpretability needs.
- To propose frameworks for responsible implementation of agentic AI in radiology.
Main Methods:
- Analysis of emerging multi-agent radiological workflows.
- Examination of how agent interactions and distributed decision-making create layers of inscrutability.
- Review of traditional explainable AI limitations in complex, multi-step AI reasoning processes.
Main Results:
- Multi-agent AI systems in radiology create 'compound opacity' due to agent interactions and distributed decision-making.
- The increasing capability of radiological AI presents an autonomy-transparency paradox, challenging clinical trust and regulatory oversight.
- Existing explainable AI methods are insufficient for understanding the multi-step reasoning of these complex AI networks.
Conclusions:
- Agentic AI in radiology necessitates novel approaches to transparency and accountability.
- Frameworks for responsible implementation must balance diagnostic innovation with essential medical transparency.
- Addressing compound opacity is crucial for fostering trust and ensuring regulatory compliance in advanced AI-driven radiology.
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