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Polymer-Based Scaffolds Incorporating Selected Essential Oil Components for Wound Healing: A Review.

Vuyolwethu Khwaza¹, Opeoluwa O Oyedeji¹

¹Department of Chemical and Earth Sciences, Faculty of Science and Agriculture, University of Fort Hare, Alice 5700, South Africa.

|October 29, 2025

Summary

Polymer scaffolds loaded with essential oil components accelerate wound healing. These advanced materials offer enhanced antimicrobial and anti-inflammatory properties for effective wound management.

Keywords:

essential oils films hydrogels nanofibers polymers wound dressings wound healing

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Area of Science:

Biomaterials Science
Polymer Chemistry
Wound Healing Research

Background:

Wound treatment faces challenges, especially with chronic and infected wounds, leading to delayed healing.
Polymer-based scaffolds show promise in wound management by mimicking the extracellular matrix and supporting tissue regeneration.
A moist wound environment is crucial for effective healing.

Purpose of the Study:

To review recent advancements in polymer-based scaffolds incorporating essential oil (EO) components for wound healing.
To emphasize the role of these scaffolds in promoting effective wound healing.
To provide a comprehensive overview of design and application strategies.

Main Methods:

Systematic literature review of polymeric scaffolds and EO-based bioactive agents.
Focus on studies investigating biological activities, fabrication techniques, and therapeutic performance.
Analysis of EO-loaded scaffolds in wound management.

Main Results:

EO components, like thymol and carvacrol, possess antimicrobial, anti-inflammatory, antioxidant, and analgesic properties.
Incorporation into polymer matrices enhances scaffold biocompatibility and antimicrobial efficacy.
Synergistic interactions between EOs and polymers promote tissue regeneration.

Conclusions:

Integrating EO components into polymer scaffolds offers a promising strategy for multifunctional wound dressings.
These systems leverage polymer structural benefits and EO therapeutic advantages.
EO-loaded polymer scaffolds provide an effective platform for accelerated healing and infection prevention.