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Related Concept Videos

Appendicitis-I: Introduction01:22

Appendicitis-I: Introduction

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The appendix, a small, narrow, blind tube extending from the inferior part of the cecum, is widely regarded as a vestigial organ, having lost much of its original function through evolution. Despite its diminished role, the appendix can become inflamed, a condition known as appendicitis.
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
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Appendicitis-II: Diagnostic Studies and Management01:29

Appendicitis-II: Diagnostic Studies and Management

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Diagnosing and managing appendicitis requires a structured and comprehensive approach that spans from initial assessment to postoperative care. Here is an overview of the process:
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...
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Teeth01:15

Teeth

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The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin...
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Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

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The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
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Tooth Anatomy01:21

Tooth Anatomy

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The human tooth enables us to eat a variety of foods, speak clearly, and even aid in shaping our faces. Teeth are composed of various elements that work together. Here's a detailed look at the anatomy of a human tooth.
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or...
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Updated: Jan 13, 2026

Oral Biofilm Sampling for Microbiome Analysis in Healthy Children
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Oral Biofilm Sampling for Microbiome Analysis in Healthy Children

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Tooth Eruption and Microbial Correlation in Pediatric Appendicitis: An Exploratory Case-Control Study.

Wieland Elger1, Carlotta Blod2, Sara Schülin2

  • 1Department of Pediatric Dentistry and Primary Prevention, University Leipzig, 04103 Leipzig, Germany.

Journal of Clinical Medicine
|October 29, 2025
PubMed
Summary
This summary is machine-generated.

Tooth eruption may be linked to pediatric appendicitis, with more erupting teeth found in affected children. Further research is needed to confirm this potential oral health connection.

Keywords:
dental characteristicsdental developmentoral microbiotaoral sampling sitespediatric appendicitis

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Area of Science:

  • Microbiology
  • Pediatric Health
  • Oral Health

Background:

  • The oral cavity is a potential pathogen reservoir for pediatric appendicitis.
  • Previous studies noted oral-appendix microbial similarities but no dental clinical associations.

Purpose of the Study:

  • Analyze detailed dental variables (eruption status, caries, hygiene, PSI) for appendicitis links.
  • Compare buccal mucosa and dental sulcus sampling sites for appendix microbiota correlation.

Main Methods:

  • Secondary analysis of clinical and microbiological data from 36 children.
  • Quantitative PCR (qPCR) assessed bacterial mRNA in appendix and oral samples.
  • Standardized dental examinations provided clinical variables.

Main Results:

  • No significant differences in caries indices, PSI, or oral hygiene behavior.
  • Appendicitis patients had more erupting teeth (3.82 vs. 1.68; p=0.021).
  • Oral sampling sites showed similar, weak correlations with appendix microbiota.

Conclusions:

  • Tooth eruption may be associated with pediatric appendicitis.
  • This association is speculative and requires larger study validation.
  • Further investigation into oral-appendix microbial dynamics is warranted.