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Updated: Jun 25, 2026

Laparoscopy-endoscopy Cooperative Surgery for the Treatment of Gastric Gastrointestinal Stromal Tumors
Published on: February 19, 2022
Ruptured Gastrointestinal Stromal Tumor in a 12-Year-Old Child: A Case Report
Ashwin Rajkumar J1, Prakash Agarwal1,2, Madhu R1
1Pediatric Surgery, Sri Ramachandra Institute of Higher Education and Research, Chennai, IND.
Insights
Pediatric gastrointestinal stromal tumors (GISTs) are rare but can be aggressive. This case highlights the need for prompt diagnosis, surgery, and imatinib therapy for better outcomes in children.
Area of Science:
- Pediatric Oncology
- Gastrointestinal Surgery
- Molecular Pathology
Background:
- Gastrointestinal stromal tumors (GISTs) are uncommon in children, often exhibiting unique clinical and molecular features.
- Pediatric GISTs can present unpredictably, posing diagnostic and management challenges.
Abstract:
Gastrointestinal stromal tumors (GISTs) are rare mesenchymal neoplasms, especially in pediatric patients, often presenting with distinct clinical and molecular characteristics. This case report describes a 12-year-old girl with a large gastric GIST complicated by tumor rupture and hemoperitoneum. Initial treatment with imatinib was followed by emergent surgical intervention due to tumor bleeding. Histopathology confirmed an epithelioid-type GIST, necessitating continued imatinib therapy. Pediatric GISTs demonstrate an indolent but unpredictable course, requiring a multidisciplinary approach. Despite their aggressive nature, pediatric cases show better survival outcomes than adults. This case underscores the importance of timely intervention, individualized therapy, and long-term follow-up to improve prognosis in children with GISTs.
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