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Electrical Stimulation Combined With Hydroxyapatite Hydrogel for Bone Regeneration.

Jingjing Gao¹, Xue Wang¹, Ziming Ma¹

¹School of Basic Medical Sciences, Clinical Medical College & Affiliated Hospital of Chengdu University, Chengdu, People's Republic of China.

Journal of Biomedical Materials Research. Part B, Applied Biomaterials

|October 29, 2025

Summary

This study introduces a strontium-doped hydroxyapatite and chitosan (Sr-HA@CS) biocomposite that enhances bone regeneration. Combined with electrical stimulation (ES), it significantly accelerates bone healing and osteogenesis.

Keywords:

bone regeneration electrical stimulation hydrogel hydroxyapatite

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Area of Science:

Biomaterials Science
Regenerative Medicine
Orthopedic Research

Background:

Bone tissue possesses bioelectrical properties crucial for healing.
Electrical stimulation (ES) is a known accelerator of bone repair.
Biocomposite materials synergizing with ES for bone defect repair require further investigation.

Purpose of the Study:

To synthesize and evaluate a strontium-doped hydroxyapatite and chitosan (Sr-HA@CS) composite for bone regeneration.
To investigate the synergistic effects of the Sr-HA@CS composite with electrical stimulation (ES).

Main Methods:

Synthesis of strontium-doped hydroxyapatite and chitosan (Sr-HA@CS) composite.
Evaluation of composite properties including injectability, biocompatibility, and osteoinductivity.
RNA sequencing analysis to assess osteogenesis-related gene expression.
In vivo assessment of bone regeneration.

Main Results:

The Sr-HA@CS composite demonstrated excellent injectability, biocompatibility, and osteoinductivity.
Combined ES and Sr-HA@CS significantly upregulated osteogenesis-related genes.
Synergistic treatment accelerated the osteogenic process, promoted intracellular calcium enrichment, and enhanced bone regeneration in vivo.

Conclusions:

The Sr-HA@CS composite shows significant potential for promoting bone regeneration.
The combination of Sr-HA@CS and ES therapy offers a promising approach for accelerating bone repair.
This synergistic strategy represents a key area for future research in bone defect treatment.