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Occupational anaphylaxis: a comprehensive review.

Regina Treudler1

  • 1Institute of Allergology, Charité, Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.

Current Opinion in Allergy and Clinical Immunology
|October 29, 2025
PubMed
Summary
This summary is machine-generated.

Occupational anaphylaxis, while rare, is often underdiagnosed. This review covers its definition, risk factors, and management, highlighting recent diagnostic criteria for workplace-related allergic reactions.

Keywords:
allergydiagnostic criteriahypersensitivitymanagementreviewworkplace

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Area of Science:

  • Allergy and Immunology
  • Occupational Health
  • Clinical Medicine

Background:

  • Occupational anaphylaxis involves severe allergic reactions from workplace exposures.
  • Current management includes emergency treatment, trigger avoidance, and safety measures.

Purpose of the Study:

  • To provide an updated overview of occupational anaphylaxis.
  • To discuss its definition, risk factors, triggers, clinical presentation, diagnosis, and management.

Main Methods:

  • Review of recent literature and expert recommendations.
  • Analysis of data on work-related anaphylaxis cases.
  • Discussion of evolving diagnostic criteria.

Main Results:

  • Work-related anaphylaxis accounts for 3.8% of cases, primarily caused by Hymenoptera venom and food allergens.
  • New expert recommendations propose criteria for diagnosing occupational anaphylaxis based on sensitization and reaction contexts.
  • Recent discussions address anaphylaxis diagnosis, grading, and management.

Conclusions:

  • Occupational anaphylaxis is likely underreported and underdiagnosed.
  • Increased awareness and standardized diagnostic criteria are needed.