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Updated: Jan 13, 2026
DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications
Published on: September 27, 2019
Dynamic nanostructures based on DNA self-assembly: from molecular switches to intelligent biomedical applications
Jiahui Wang1, Hexin Yu1, Xiangyuan Ouyang1,2
1Key Laboratory of Functional Supramolecular Structure and Materials, Key Laboratory of Synthetic and Natural Functional Molecule of Ministry of Education, College of Chemistry and Materials Science, Northwest University, Xi'an, Shaanxi 710127, P. R. China. ouyangxy@nwu.edu.cn.
Dynamic DNA nanostructures, precisely controlled by external stimuli, offer advanced capabilities for intelligent nanosystems. This review covers recent progress, applications in biomedicine and computing, and future directions for precision medicine.
Area of Science:
- Nanotechnology
- Biotechnology
- Molecular Engineering
Background:
- DNA self-assembly provides molecular precision for nanostructure construction.
- Dynamic DNA nanostructures overcome static limitations with stimulus-responsive elements.
- Recent advancements enable controllable regulation of nanoscale behaviors.
Purpose of the Study:
- To review the latest research on dynamic DNA nanostructures over the past five years.
- To introduce design principles and regulatory mechanisms for stimulus-triggered conformational changes.
- To explore applications in biomedicine and molecular computing and identify future directions.
Main Methods:
- Systematic review of recent literature (last five years).
- Analysis of design strategies for stimulus-responsive DNA nanostructures.
- Examination of applications in biomedicine and molecular computing.
Main Results:
- Dynamic DNA nanostructures exhibit precise, reversible control via stimuli like light, pH, temperature, ions, and enzymes.
- Innovative applications are emerging in biomedicine (e.g., drug delivery) and molecular computing.
- Key technical bottlenecks and future development pathways are identified.
Conclusions:
- Dynamic DNA nanostructures represent a significant advancement in programmable nanomaterials.
- These structures hold immense potential for developing intelligent, adaptive nanosystems.
- Future research will focus on precision medical interventions and overcoming current limitations.
