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Updated: Jan 13, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
CF3S-triazine for dehydroxylative trifluoromethylthiolation of alcohols
Yaling Peng1, Jun Sun2, Xu Yao1
1Institute of Pharmacy and Pharmacology, Hengyang Medicinal School, University of South China, Hengyang, Hunan, 421001, China. zhengxing9166@sohu.com.
Abstract:
Dehydroxylative trifluoromethylthiolation of alcohols has garnered significant attention yet remains a challenging transformation due to the high bond dissociation energy of the C-OH bond. In this work, we report the use of tris(trifluoromethylthio)-1,3,5-triazine as a dual-function reagent that serves both as a CF3S source and an activator of hydroxyl groups. The reaction proceeds under mild conditions, does not require Lewis acid activators, and converts a range of primary alcohols to the corresponding products in good to excellent yields.
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