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M6AREG 2.0: the landscape of m6A-centered crosstalk with diverse epigenetic regulation

Mengjie Yang1,2, Ying Zhou1,3, Liting Yang2

  • 1The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China.

Nucleic Acids Research
|October 29, 2025
PubMed

Insights

The M6AREG database now comprehensively includes m6A-centered crosstalk (m6A-CT) data, covering epigenetic regulation, diseases, and drug responses. This update enhances understanding of m6A-CT for biomarker discovery and therapeutic development.

Area of Science:

  • Epigenetics and Molecular Biology
  • RNA Biology
  • Bioinformatics

Background:

  • m6A-centered crosstalk (m6A-CT) with epigenetic regulation is crucial for disease development and drug response.
  • Existing databases lack comprehensive m6A-CT data, hindering research.
  • m6A-CT involves interactions with histone modifications, DNA methylation, RNA modifications, and non-coding RNAs.

Purpose of the Study:

  • To update the M6AREG database with comprehensive m6A-CT data.
  • To provide a centralized resource for m6A-CT, epigenetic regulators, associated diseases, and drug responses.
  • To facilitate research in identifying diagnostic biomarkers, therapeutic targets, and drug discovery related to m6A modification.

Main Methods:

  • Database update and curation of m6A-CT entries.
  • Classification of m6A-CT into four categories: m6A-HistMod, m6A-DNAMeth, m6A-RNAMod, and m6A-ncRNA.
  • Inclusion of data on 271 diseases and 205 drug responses regulated by 585 epigenetic regulators.

Main Results:

  • The updated M6AREG database contains 713 m6A-HistMod, 300 m6A-DNAMeth, 483 m6A-RNAMod, and 939 m6A-ncRNA entries.
  • The database links m6A-CT to 271 disease categories and 205 drug responses.
  • Data on 585 epigenetic regulators (138 proteins, 447 non-coding RNAs) are integrated.

Conclusions:

  • The enhanced M6AREG database provides critical data for m6A-CT studies.
  • This resource is vital for identifying diagnostic biomarkers and therapeutic targets.
  • The update supports drug discovery, combinatorial therapies, and overcoming drug resistance or immune evasion.

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