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Related Experiment Video

Updated: Jan 13, 2026

Three-dimensional Imaging and Analysis of Mitochondria within Human Intraepidermal Nerve Fibers

Three-dimensional Imaging and Analysis of Mitochondria within Human Intraepidermal Nerve Fibers

Published on: September 29, 2017

Pattern Recognition Approach to Neuropathy and Neuronopathy.

Richard J Barohn¹, Gil I Wolfe², David S Saperstein³

¹Department of Neurology, School of Medicine, University of Missouri, Columbia, USA.

Neurologic Clinics

|October 29, 2025

Summary

This summary is machine-generated.

This study outlines a diagnostic approach for neuropathic disorders, including neuronopathies and peripheral nerve conditions. It details a 7-question framework to classify patients into 11 patterns, guiding differential diagnosis and laboratory testing.

Keywords:

Distal Motor Neuronopathy Neuropathy Patterns Proximal Sensory Symmetric or asymmetric

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Last Updated: Jan 13, 2026

Three-dimensional Imaging and Analysis of Mitochondria within Human Intraepidermal Nerve Fibers

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Published on: September 29, 2017

Nerve Ultrasound Protocol to Detect Dysimmune Neuropathies

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Published on: October 7, 2021

Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1

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Published on: February 13, 2018

Area of Science:

Neurology
Clinical Neuroscience

Background:

Neuropathic disorders affect neurons, encompassing neuronopathies and peripheral nerve issues like radiculopathy, plexopathy, and neuropathy.
Accurate diagnosis is crucial for effective treatment of these complex neurological conditions.

Purpose of the Study:

To present a structured clinical approach for diagnosing neuropathic disorders.
To guide clinicians in differentiating between various neuropathic conditions through a systematic evaluation.

Main Methods:

A diagnostic framework based on a 7-question clinical assessment is proposed.
Patients are categorized into 11 distinct patterns derived from history and neurologic examination findings.

Main Results:

The 11 identified patterns facilitate a narrowed differential diagnosis for neuropathic disorders.
This systematic approach aids in selecting appropriate laboratory studies for confirmation.

Conclusions:

A structured, question-based history and examination can effectively classify patients with neuropathic disorders.
This method enhances diagnostic accuracy and streamlines the workup of neurological conditions.