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Nutritional Neuropathies.

Matthew Varon1, Mamatha Pasnoor1, Mazen M Dimachkie2

  • 1Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA.

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|October 29, 2025
PubMed
Summary
This summary is machine-generated.

Cryptogenic sensory polyneuropathy (CSPN) often affects older adults and typically presents with sensory symptoms. This review explores nutritional neuropathies, covering causes, risk factors, and management strategies.

Keywords:
Alcohol-induced peripheral neuropathyCopperMalabsorptionNeuropathyThiamineVitamin B12Vitamin EVitamin deficiency

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Area of Science:

  • Neurology
  • Nutritional Science

Background:

  • Cryptogenic or idiopathic sensory polyneuropathy (CSPN) is a frequent neurological disorder in individuals over 50.
  • CSPN is characterized by predominantly sensory symptoms, with minimal or absent motor involvement.
  • Standard laboratory and electrophysiological tests often fail to identify a specific cause for CSPN.

Purpose of the Study:

  • To review the diverse etiologies of nutritional neuropathies.
  • To describe the varied clinical presentations of nutritional neuropathies.
  • To discuss epidemiological factors, risks, prevention, and treatment for nutritional neuropathies.

Main Methods:

  • Literature review of nutritional neuropathies.
  • Analysis of syndromes related to nutritional deficiency and excess.
  • Examination of epidemiological data and risk factors.

Main Results:

  • Nutritional factors, both deficiency and excess, are significant contributors to polyneuropathy.
  • Specific nutritional syndromes present with distinct clinical features and risk profiles.
  • Skin biopsy can aid in the diagnosis of some neuropathies.

Conclusions:

  • Nutritional imbalances are crucial considerations in the differential diagnosis of sensory polyneuropathy.
  • Understanding the epidemiology and risk factors is key to preventing nutritional neuropathies.
  • Tailored prevention and treatment strategies are essential for managing nutritional polyneuropathies.