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Updated: Jan 12, 2026

A Simple Benchtop Filtration Method to Isolate Small Extracellular Vesicles from Human Mesenchymal Stem Cells
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Microgravity-driven Rab27B activation amplifies mesenchymal stem cell-derived extracellular vesicle production and

Yi Ding1,2,3, Yiru Fu1,4, Meng Sun1,2,3

  • 1Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi Wu Lu No.98, Xi'an, Shaanxi, China.

Stem Cell Research & Therapy
|October 30, 2025
PubMed
Summary

Microgravity culture significantly boosts mesenchymal stem cell-derived extracellular vesicle (MSC-EVs) production and enhances their therapeutic properties. This novel approach addresses manufacturing challenges for EVs in regenerative medicine.

Keywords:
Extracellular vesiclesImmunomodulatoryMicrogravityRab27BTissue repair and regeneration

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