Related Experiment Video
Updated: Jan 12, 2026
07:26
Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents
Published on: July 14, 2021
5.5K
Comparing Cardiac Reverse Remodeling in Aortic Stenosis With Surgical and Transcatheter Aortic Valve Replacement.
Koichi Inoue1, Koichi Maeda1, Kyongsun Pak2
1Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Osaka, Japan.
Annals of Thoracic Surgery Short Reports
|October 30, 2025
Summary
Surgical aortic valve replacement (SAVR) shows superior left ventricular mass regression compared to transcatheter aortic valve replacement (TAVR) in patients with aortic stenosis. This finding is crucial for long-term patient management and treatment selection.
Area of Science:
- Cardiology
- Cardiovascular Surgery
- Medical Imaging
Background:
- Left ventricular reverse remodeling, or mass regression, post-aortic valve replacement is linked to better clinical outcomes in aortic stenosis patients.
- The comparative impact of surgical aortic valve replacement (SAVR) versus transcatheter aortic valve replacement (TAVR) on left ventricular mass regression remains incompletely understood.
- This study aimed to directly compare left ventricular mass changes following SAVR and TAVR.
Purpose of the Study:
- To compare the efficacy of SAVR and TAVR in promoting left ventricular mass regression.
- To evaluate the time course of left ventricular mass changes up to one year post-intervention.
- To identify factors associated with left ventricular mass regression after aortic valve replacement.
Main Methods:
- A cohort of 1939 patients with aortic stenosis undergoing isolated SAVR or TAVR was analyzed.
- Propensity score matching created a 1:1 matched cohort of 247 pairs for comparison.
- Left ventricular mass regression was assessed using echocardiography up to one year post-procedure.
Main Results:
- SAVR resulted in significantly greater left ventricular mass regression than TAVR at both 30 days (SAVR: -11.2% vs. TAVR: -2.6%) and 1 year (SAVR: -23.8% vs. TAVR: -13.8%).
- Multivariable analysis indicated that higher baseline left ventricular mass index, undergoing SAVR, and absence of moderate or greater paravalvular leakage were associated with improved regression.
- The odds of left ventricular mass regression were significantly higher with SAVR (OR, 2.54) compared to TAVR.
Conclusions:
- Surgical aortic valve replacement demonstrates superior left ventricular mass regression compared to transcatheter aortic valve replacement in a propensity-matched cohort.
- The choice between SAVR and TAVR has significant implications for left ventricular remodeling.
- Optimizing valve selection is critical for the lifetime management of patients with aortic stenosis.
More Related Videos
Related Concept Videos
01:25Aortic Regurgitation III: Medical Management
385
Aortic regurgitation (AR) is when the aortic valve does not close or seal properly, leading to backward blood circulation from the aorta into the left ventricle during diastole. Common causes of AR include rheumatic heart disease, congenital valve defects, and aortic root dilation. Managing AR requires a multifaceted approach to alleviate symptoms, preserve left ventricular function, and address the underlying cause of the regurgitation. Patients with symptomatic AR or significant left...
385
01:22Aortic Regurgitation II: Clinical Features and Diagnostic Tests
394
Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
394
01:15Aortic Regurgitation I: Introduction
456
IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
456