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Updated: Jan 12, 2026

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Murine Renal Transplantation Procedure
Published on: July 10, 2009
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Acute Tubular Necrosis Following Renal Transplantation: A Case Report
Md Rezaul Alam1, Ferdous Jahan1, A H Hamid Ahmed1
1Nephrology, Bangladesh Medical University (BMU), Dhaka, BGD.
Cureus
|October 30, 2025
Summary
Acute tubular necrosis (ATN) is a common cause of delayed graft function after kidney transplants. This case highlights how cyclosporine can worsen ATN, impacting graft survival.
Area of Science:
- Nephrology
- Transplantation Immunology
Background:
- Acute tubular necrosis (ATN) is a primary cause of delayed graft function (DGF) post-renal transplantation.
- Ischemia-reperfusion injury and calcineurin inhibitor (CNI) nephrotoxicity, like that from cyclosporine, are key contributors to ATN.
- ATN complicates early graft function, affects long-term survival, and is diagnostically challenging due to overlap with acute rejection.
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