Related Experiment Video
Updated: Jan 12, 2026
Author Spotlight: Oral Candida Diagnosis to Advance Clinical Treatment Regimen for pSS Patients
Published on: March 1, 2024
T-cell depletion and oral candidiasis in Kyasanur Forest disease: a case series
Nitin Gupta1, Pothumarthy Venkata Swathi Kiran1, Anjely Sebastian1
1Department of Infectious Diseases, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka 576104, India.
Background:
Kyasanur Forest Disease (KFD) is a tick-borne viral haemorrhagic fever endemic to southern India.
Methods:
We present a case series of five PCR-confirmed patients with KFD who developed oral candidiasis. CD4 and CD8 T-lymphocyte counts were measured using flow cytometry alongside detailed clinical assessment.
Results:
All five patients with candidiasis had CD4 counts <300 cells/µl, and four had CD8 counts <200 cells/µl. None had other known immunosuppressive conditions.
Conclusion:
CD4 and CD8 lymphopenia are consistent and clinically relevant features among patients with KFD who developed oral candidiasis, suggesting transient mucosal immune suppression as a potential pathogenic mechanism.
