Clinical and Laboratory Insights Into the GentleWave System: A Scoping Review

Area of Science:

• Endodontics
• Dental Technology
• Regenerative Medicine

Background:

• The GentleWave System is an advanced endodontic irrigation technology using multisonic energy.
• It aims to enhance root canal cleaning and disinfection.
• Its comparative clinical effectiveness and long-term benefits require further investigation.

Purpose of the Study:

• To systematically assess the available clinical and laboratory evidence on the GentleWave System in endodontics.
• To evaluate its efficacy in root canal cleaning and disinfection.
• To identify research gaps regarding its clinical effectiveness and cost-efficiency.

Main Methods:

• A comprehensive search of 5 electronic databases was performed.
• Studies were identified following Preferred Reporting Items for Systematic Review and Meta-analysis Extension for Scoping Reviews guidelines.
• Included studies were clinical and in vitro investigations of the GentleWave System.

Main Results:

• 34 studies were included: 28 laboratory (82.4%) and 6 clinical (17.6%).
• Clinical trials reported >97% periapical healing rates and comparable postoperative pain to passive ultrasonic irrigation.
• Laboratory studies showed effective removal of biofilm, smear layer, and filling materials with minimal dentin erosion.

Conclusions:

• The GentleWave System shows potential as an adjunctive irrigation technology, especially for complex root canal anatomy.
• Evidence quality is low to moderate due to limited clinical studies and high risk of bias.
• Further high-quality clinical research is warranted to confirm its efficacy and long-term outcomes.