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Updated: Jan 12, 2026

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3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
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Neuroimaging and Diagnostic Workup for Headache
Mehak Majid Khan1, Prabath Mondel2, Hsiangkuo Yuan1
1Jefferson Headache Center, Department of Neurology, Thomas Jefferson University, 900 Walnut Street, Suite 200, Philadelphia, PA 19107, USA.
Physical Medicine and Rehabilitation Clinics of North America
|October 30, 2025
Summary
Neuroimaging aids headache diagnosis but requires careful, evidence-based use. Optimizing imaging selection prevents overutilization and missed diagnoses for better patient outcomes.
Area of Science:
- Neurology
- Radiology
- Medical Imaging
Background:
- Neuroimaging is crucial for evaluating headache disorders.
- Clinical assessment is fundamental, but imaging is essential for specific diagnoses.
- Overutilization and inappropriate selection of imaging studies pose challenges.
Purpose of the Study:
- To examine the role of neuroimaging in primary and secondary headache disorders.
- To discuss the strengths and limitations of various neuroimaging modalities.
- To provide a framework for efficient and effective neuroimaging utilization.
Main Methods:
- Review of current literature and guidelines on neuroimaging in headache.
- Analysis of the utility of different imaging modalities (e.g., MRI, CT).
- Development of a practical framework for optimizing imaging selection.
Main Results:
- Neuroimaging is vital for diagnosing many headache disorders when used judiciously.
- Guidelines exist, yet challenges in overutilization and missed diagnoses persist.
- Different modalities have specific strengths and limitations for various headache types.
Conclusions:
- A comprehensive clinical evaluation is paramount in headache diagnosis.
- Evidence-based neuroimaging selection is key to optimizing diagnostic accuracy and resource efficiency.
- Implementing a practical framework can improve neuroimaging utilization in headache management.
Keywords:
HeadacheIdiopathic intracranial hypertensionImagingMigraineRCVSSecondary headacheSpontaneous intracranial hypotensionThunderclap headache
