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Medication Overuse Headache

Jennifer T Nguyen1, Sunita Dergalust1, Udai Nanda2

  • 1Department of Neurology, West Los Angeles VA Medical Center, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA.

Physical Medicine and Rehabilitation Clinics of North America
|October 30, 2025
PubMed

Insights

Medication overuse headache (MOH) is a prevalent secondary headache disorder affecting 1-5% of individuals. It arises from the regular overuse of acute headache treatments in those with pre-existing primary headaches.

Area of Science:

  • Neurology
  • Headache Medicine

Background:

  • Medication overuse headache (MOH) is a secondary headache disorder.
  • It affects 1-5% of the population.
  • MOH develops from regular overuse of acute headache treatments.

Purpose of the Study:

  • To define Medication Overuse Headache (MOH).
  • To identify risk factors for MOH.

Main Methods:

  • Literature review on MOH definition and prevalence.
  • Analysis of risk factors associated with MOH development.

Main Results:

  • MOH is characterized by headaches occurring >15 days/month.
  • Pre-existing primary headache disorders are the primary risk factor for MOH.

Conclusions:

  • MOH is a common condition linked to acute medication overuse.
  • Identifying and managing pre-existing headache disorders is crucial for MOH prevention.
Keywords:
Drug-induced headacheMedication overuse headacheMultidisciplinary headache managementRebound headacheSecondary headacheWithdrawal headache

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