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Area-Level Income Disparities and the Timing of First Ischemic Stroke: Insights From the 2019 National Inpatient
Sonia Jahangiri1,2, Ajith Vemuri3, Alireza Vafaei Sadr1
1Department of Public Health Sciences, College of Medicine Pennsylvania State University Hershey PA USA.
Journal of the American Heart Association
|October 31, 2025
Summary
Lower income is linked to earlier first ischemic strokes, particularly for White individuals and women. This highlights significant socioeconomic disparities in stroke incidence and age of onset.
Area of Science:
- Public Health
- Epidemiology
- Health Disparities
Background:
- Socioeconomic status significantly influences health outcomes, including the age of first ischemic stroke.
- Investigating the link between income and stroke incidence is crucial for understanding health inequalities.
Purpose of the Study:
- To examine the relationship between ZIP-code level median income and the age of first ischemic stroke.
- To identify disparities in stroke onset age based on socioeconomic status, race, and sex.
Main Methods:
- Utilized the 2019 National Inpatient Sample database, identifying patients over 18 with ischemic stroke.
- Employed multivariate linear regression, adjusting for sex, race, patient location, and comorbidities.
- Analyzed the impact of area-level income on the age at first ischemic stroke.
Main Results:
- The average age of first ischemic stroke was 70.1 years; individuals in the lowest income group had strokes 4.3 years earlier than the highest income group.
- After adjustments, higher income was associated with a 2.1-year delay in first ischemic stroke onset.
- Disparities were observed across racial and sex groups, with White individuals and women experiencing strokes at younger ages.
Conclusions:
- Lower income levels are significantly associated with a younger age at first ischemic stroke.
- Socioeconomic status-related disparities in stroke incidence are evident, particularly affecting White individuals and women.
- Further research is needed to explore the underlying factors contributing to these disparities.
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