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Updated: Jan 12, 2026
Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss
Published on: January 25, 2016
Prognostic Value of the Triglyceride-Glucose Index in Idiopathic Sudden Sensorineural Hearing Loss
Yatian Liu1, Jialian Feng1, Jianguo He1
1Department of Otolaryngology, The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, China.
Objective:
To evaluate the association between the triglyceride-glucose (TyG) index and the hearing prognosis in patients with idiopathic sudden sensorineural hearing loss (ISSNHL).
Materials And Methods:
This retrospective study included 63 hospitalized patients with ISSNHL and 32 healthy controls. Clinical data, including audiological assessment, fasting triglyceride (TG), fasting plasma glucose (FPG), and TyG index, were analyzed. Treatment outcomes were classified as good (≥15 dB improvement) or poor (<15 dB). Univariate and multivariate logistic regression were performed, with age, degree of hearing loss, and TyG index included as covariates. Post hoc power analysis was applied to nonsignificant results.
Results:
Compared to the healthy group, ISSNHL patients had significantly higher FPG (110.46 mg/dL vs 84.96 mg/dL, P < .001) but lower TG levels (75.28 mg/dL vs 113.81 mg/dL, P = .036). The TyG index did not differ significantly (8.46 ± 0.78 vs 8.50 ± 0.54, P = .825). Within the ISSNHL cohort, only baseline hearing loss severity predicted prognosis (P = .038). TyG index showed a nonsignificant inverse trend (OR 0.52, 95% CI 0.22-1.19, P = .105). Post hoc analysis indicated limited statistical power (≈38%), suggesting potential Type II error.
Conclusions:
The TyG index was not independently associated with prognosis in ISSNHL, though metabolic alterations were evident. Initial hearing loss severity remained the strongest predictor of recovery. Larger prospective studies with extended follow-up and metabolic monitoring are needed to validate these findings and refine individualized management strategies.
