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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Enhancing Chimeric Antigen Receptor-Extracellular Vesicles (CAR-EV) Technology: The Future of Cancer Therapy

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VLP-based Cancer Therapy: Past, Present, and Future Prospects.

Amisha S Raikar1, Swaroop Kumar Pandey2, Ayush Kulshreshtha2

  • 1Department of Pharmaceutics, PES Rajaram and Tarabai Bandekar College of Pharmacy, Farmagudi, Ponda, Goa, 403401, India.

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Virus-like particles (VLPs) show promise for targeted cancer therapy by mimicking viruses to deliver treatments and stimulate immune responses. Further research is needed to overcome challenges and enhance the clinical efficacy of VLP-based cancer treatments.

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Cancer therapyimmunotherapytargeted treatmentvirus-like particles VLPs.

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Area of Science:

  • Oncology
  • Virology
  • Immunology

Background:

  • Virus-like particles (VLPs) are emerging as a significant tool in cancer research.
  • VLPs structurally mimic viruses but lack genetic material, offering unique therapeutic advantages.
  • They can target cancer cells, elicit immune responses, and deliver therapeutic payloads.

Purpose of the Study:

  • To provide a comprehensive review of VLP-based cancer therapy.
  • To elucidate mechanisms of action, types of VLPs, and study outcomes.
  • To identify challenges and future directions in VLP cancer treatment.

Main Methods:

  • Review of preclinical studies in animal models.
  • Analysis of early-phase clinical trial data.
  • Examination of VLP mechanisms including apoptosis induction and immune-mediated cytotoxicity.

Main Results:

  • VLPs demonstrate preclinical efficacy in animal models.
  • Early clinical trials indicate safety and feasibility, though efficacy varies.
  • Challenges include immunogenicity, scalability, and delivery optimization.

Conclusions:

  • VLP-based therapy holds substantial potential as a novel cancer treatment modality.
  • Further research into combination therapies and personalized medicine can enhance VLP efficacy.
  • VLPs offer hope for improved patient outcomes and quality of life in cancer care.