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Significance of circular RNAs in regulating protein ubiquitination for malignant tumor progression

Haidong Zhong1,2,3, Wei Li1,2,3, Peiyue Luo1,2,3

  • 1The First Clinical College, Gannan Medical University, Ganzhou, Jiangxi, China.

Frontiers in Immunology
|October 31, 2025
PubMed

Insights

Circular RNAs (circRNAs) regulate protein degradation through the ubiquitin-proteasome system, impacting cancer development. Understanding these circRNA mechanisms offers potential for precise cancer therapies.

Area of Science:

  • Molecular Biology
  • Biochemistry
  • Oncology

Background:

  • Circular RNAs (circRNAs) are non-coding RNAs formed by mRNA back-splicing.
  • Aberrant circRNA expression is linked to cancer initiation and progression.
  • Ubiquitination targets proteins for proteasomal degradation, a key cellular process.

Purpose of the Study:

  • To systematically review mechanisms of circRNA regulation of protein ubiquitination.
  • To explore how circRNAs modulate cancer signaling pathways and tumorigenesis.
  • To highlight the therapeutic potential of circRNAs in cancer treatment.

Main Methods:

  • Literature review of studies on circRNAs, ubiquitination, and cancer.
  • Systematic summary of molecular mechanisms.
  • Analysis of signaling pathways and tumorigenesis roles.

Main Results:

  • CircRNAs precisely regulate target protein ubiquitination.
  • These interactions modulate key cancerous signaling pathways.
  • CircRNAs play a significant role in controlling tumor development.

Conclusions:

  • CircRNAs are intricately involved in protein degradation via the ubiquitin-proteasome system.
  • CircRNAs represent promising targets for future cancer therapies.
  • Further research is needed to fully elucidate complex circRNA-protein interactions.
Keywords:
cancer therapycircRNAimmunotherapymalignant tumorubiquitination

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