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Induction of Nephrotic Syndrome in Mice by Retrobulbar Injection of Doxorubicin and Prevention of Volume Retention by Sustained Release Aprotinin
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Clinical pattern of nephrotic syndrome and treatment response in children

Rahul Gedam1, Gaurav Kumar Prajapati2, Ankit Kumar Pawar3

  • 1Department of Pediatrics, Netaji Subhash Chandra Bose Medical College, Jabalpur, Madhya Pradesh, India.

Bioinformation
|October 31, 2025
PubMed

Insights

Nephrotic syndrome in children aged 1-10 is common in males, with edema as a key symptom. Most children respond well to steroid treatment, though some cases are steroid-resistant.

Area of Science:

  • Pediatrics
  • Nephrology

Background:

  • Nephrotic syndrome is a significant kidney disorder in children.
  • Understanding its presentation and treatment response is crucial for pediatric care.

Purpose of the Study:

  • To investigate the clinical presentation, laboratory findings, complications, and initial therapeutic responses in children with nephrotic syndrome.
  • To analyze patterns in a specific pediatric cohort.

Main Methods:

  • A prospective observational study was conducted over eighteen months.
  • 164 children aged 1 to 10 years were included.
  • Data collected from a pediatric ward and outpatient department.

Main Results:

  • Nephrotic syndrome was more prevalent in males.
  • Edema was a universal presenting symptom.
  • A significant proportion of children experienced relapses.
  • Most patients responded to steroid therapy, but some showed steroid resistance or dependence.

Conclusions:

  • Steroids are effective for most pediatric nephrotic syndrome cases.
  • Identifying steroid-resistant or dependent cases is important for management.
  • Further research may explore long-term outcomes and alternative treatments.

Keywords:
Nephrotic syndromechildrencomplicationsrelapserenal functionsteroid response

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