High-Performance Olfactory Receptor-Derived Peptide Biosensor for Acetic Acid Gas Detection Based on Polystyrene...

Area of Science:

• Environmental Science
• Materials Science
• Biotechnology

Background:

• Acetic acid gas is a hazardous organic pollutant requiring real-time detection.
• Low-concentration detection is critical for environmental and health monitoring.
• Existing detection methods have limitations in sensitivity and response time.

Purpose of the Study:

• To develop a highly sensitive and selective bioelectronic sensor for acetic acid gas.
• To enhance sensor performance using polystyrene microsphere templating.
• To evaluate the sensor's detection limit, selectivity, stability, and response time.

Main Methods:

• Synthesized a bioelectronic sensor by linking N-terminal cysteine-modified olfactory receptor-derived peptide with thioester-functionalized single-walled carbon nanotubes.
• Employed polystyrene microsphere templating during sensor synthesis to improve performance.
• Conducted characterization and gas sensitivity tests at room temperature.

Main Results:

• The templated sensor exhibited significantly improved performance compared to the non-templated version.
• Achieved an ultra-low detection limit of 1 part-per-trillion (ppt) for acetic acid gas.
• Demonstrated excellent selectivity, stability, and rapid response characteristics, outperforming conventional devices.

Conclusions:

• Polystyrene microsphere templating is an effective strategy for enhancing bioelectronic sensor performance.
• The developed sensor offers a highly sensitive, selective, and stable platform for real-time acetic acid gas detection.
• This advancement has significant implications for environmental monitoring and human health protection.