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Signal-Inversion Strategy-Mediated Dual-Wavelength Ratiometric ECL Sensing for Sensitive Detection of 5F-ADB.

Xiaolan Wang1,2, Ding Jiang1,3, Wei Zhang4

  • 1Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology, School of Petrochemical Engineering, Changzhou University, Changzhou, Jiangsu 213164, China.

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A novel dual-wavelength ratiometric electrochemiluminescence (ECL) sensor utilizing Zr-MOF was developed for highly sensitive 5F-ADB detection. This sensor achieves a low detection limit and shows promise for e-cigarette sample analysis.

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Area of Science:

  • Analytical Chemistry
  • Materials Science
  • Nanotechnology

Background:

  • Developing sensitive detection methods for trace analytes is crucial.
  • Ratiometric electrochemiluminescence (ECL) offers advantages for signal stability and accuracy.
  • Metal-organic frameworks (MOFs) show potential as modulators in ECL systems.

Purpose of the Study:

  • To design a dual-wavelength ratiometric ECL sensor for sensitive detection of 5F-ADB.
  • To utilize Zr-MOF as a bidirectional modulator to achieve signal reversal.
  • To explore the sensor's performance in real-world samples like e-cigarettes.

Main Methods:

  • Fabrication of a dual-wavelength ratiometric ECL sensor incorporating Zr-MOF.
  • Investigating the role of Zr-MOF in enhancing cathodic ECL signals via coreaction promotion.
  • Analyzing the quenching of anodic ECL signals through electrochemiluminescence resonance energy transfer (ECL-RET).
  • Employing a dual-aptamer recognition system for enhanced specificity.

Main Results:

  • The sensor demonstrated a complete reversal of dual ECL signals at distinct wavelengths.
  • Zr-MOF enhanced the cathodic ECL signal (475 nm) by promoting K2S2O8 decomposition.
  • Zr-MOF induced ECL-RET, quenching the anodic ECL signal (650 nm).
  • Achieved an ultra-low detection limit of 4.06 × 10^-15 g/L for 5F-ADB.

Conclusions:

  • The developed Zr-MOF-based dual-wavelength ratiometric ECL sensor provides highly sensitive and reliable detection of 5F-ADB.
  • The sensor exhibits practical applicability, validated by satisfactory recovery in e-cigarette samples.
  • This work offers a new strategy for developing advanced biosensors and drug-monitoring devices.