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Updated: Jan 12, 2026
08:35
Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion
Published on: May 26, 2022
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Ultrasound-Based Renal Sympathetic Denervation as Adjunctive Upstream Therapy During Atrial Fibrillation Ablation:
William Whang1, Devi Nair2, Rahul Bhardwaj3
1Mount Sinai Fuster Heart Hospital, New York, New York, USA.
JACC. Clinical Electrophysiology
|October 31, 2025
Summary
Adjunctive renal denervation (RDN) with ultrasound catheter during atrial fibrillation (AF) ablation was safe and showed a trend toward improved rhythm outcomes in hypertensive patients. Further trials are needed to confirm RDN
Area of Science:
- Cardiology
- Interventional Cardiology
- Nephrology
Background:
- Renal denervation (RDN) targets the sympathetic nervous system to improve atrial fibrillation (AF) control.
- Previous studies primarily included patients with uncontrolled hypertension.
Purpose of the Study:
- To evaluate ultrasound catheter RDN's efficacy in improving rhythm outcomes for hypertensive patients undergoing AF ablation.
- To assess RDN's safety in this patient population.
Main Methods:
- A randomized, sham-controlled, single-blind trial involving 100 patients with hypertension undergoing AF ablation.
- Patients were randomized 1:1 to RDN or sham control post-ablation.
- The primary endpoint was 12-month freedom from AF/atrial flutter (AFL) off antiarrhythmic drugs.
Main Results:
- 1-year freedom from AF/AFL was 67% for RDN vs. 49% for sham (P=0.17).
- RDN showed a non-significant 35% reduction in AF/AFL recurrence (HR 0.65; P=0.23).
- No adverse events were associated with RDN.
Conclusions:
- Adjunctive RDN is safe for patients undergoing AF ablation.
- This pilot study suggests a potential benefit of RDN on rhythm outcomes, though not statistically significant.
- A larger, powered trial is necessary to confirm RDN's impact in AF ablation patients with hypertension.
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