Sentinel Lymph Node Sampling in Endometrial Cancers

The surgical staging of endometrial cancer has changed in recent years to include sentinel lymph node (SLN) biopsy as a tool to replace regional lymphadenectomy. This has afforded surgeons the ability to preserve surgical staging information, valuable for adjuvant therapy prescription, while minimizing associated morbidities, such as lymphedema. Although SLN biopsy has been established as being highly accurate in detecting metastatic disease, including in patients with high-grade cancers, future studies should focus on establishing the value of this technique with respect to patient survival and its role in concert with molecular markers to individualize and optimize treatment outcomes.