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Related Experiment Video

Updated: Jan 12, 2026

Generation and Characterization of Right Ventricular Myocardial Infarction Induced by Permanent Ligation of the Right Coronary Artery in Mice

Generation and Characterization of Right Ventricular Myocardial Infarction Induced by Permanent Ligation of the Right Coronary Artery in Mice

Published on: February 1, 2022

Postinfarction Ventricular Septal Rupture With Thin Membrane Preventing Cardiopulmonary Collapse.

James Mannion¹, Shane Ahern², Caleb Powell¹

¹Cardiology Department, Cork University Hospital, Cork, Ireland.

JACC. Case Reports

|October 31, 2025

Summary

A man developed heart failure and a ventricular septal defect after chest pain. Surgical repair of the defect and coronary artery bypass grafting were successful, preserving heart function.

Keywords:

ventricular-septal defect

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Transthoracic Echocardiography to Assess Post-Resuscitation Left Ventricular Dysfunction After Acute Myocardial Infarction and Cardiac Arrest in Pigs

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Published on: July 12, 2022

Area of Science:

Cardiology
Cardiovascular Surgery

Background:

A 53-year-old male presented with symptoms of heart failure, including dyspnea, orthopnea, and paroxysmal nocturnal dyspnea, one week post-myocardial infarction.
Clinical examination revealed hemodynamic stability despite heart failure signs and a pansystolic murmur, suggesting a significant cardiac abnormality.

Purpose of the Study:

To report a rare case of a post-myocardial infarction ventricular septal defect (VSD) presenting with a unique membranous structure.
To describe the diagnostic approach and successful surgical management of this complex cardiac condition.

Main Methods:

Diagnostic evaluation included electrocardiogram (ECG), echocardiography, and coronary angiography.
Surgical intervention involved delayed patch repair of the ventricular septal defect and coronary artery bypass grafting (CABG).

Main Results:

Echocardiography identified a large basal inferior VSD with a thin septal membrane exhibiting a small defect and left-to-right shunting.
Coronary angiography confirmed an occluded right coronary artery.
The patient underwent successful delayed patch repair and bypass graft surgery, with no requirement for presurgical hemodynamic support due to the membrane's temporary stability.

Conclusions:

A post-myocardial infarction VSD can present with unusual features, such as a thin membranous septum, which may temporarily maintain hemodynamic stability.
Timely surgical intervention, including VSD repair and revascularization, is crucial for managing such complex cardiac complications.