Long-term clinical outcomes in living kidney donors: a comparative study with matched controls

This study aimed to assess the impact of kidney donation and pre-donation factors such as age and BMI, are associated with long-term outcomes like hypertension, diabetes and GFR decline. highlighting the importance of proper donor selection and long-term follow up.

This study aims to assess long-term clinical outcomes, such as the development of hypertension, diabetes, proteinuria, and changes in kidney function, in living kidney donors following nephrectomy.

A cohort of 87 kidney donors from Erciyes University and a control group of 100 individuals with comparable demographics were monitored. Parameters such as blood pressure, BMI, GFR, and proteinuria levels were documented pre- and post-donation, and outcomes were compared within and between groups.

Multiple regression analysis revealed nephrectomy as an independent risk factor for increased hypertension incidence (p = 0.002) and a persistent reduction in GFR exceeding 20% (p < 0.001). Advanced age at donation and post-donation BMI were associated with elevated risks of hypertension and diabetes.