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Updated: Jun 20, 2026

Quantitative Assessment of Cortical Auditory-tactile Processing in Children with Disabilities
Published on: January 29, 2014
Multichannel auditory cortical responses in misophonia: A neurophysiological investigation
Kamalakannan Karupaiah1, Rakesh Trinesh2, Ajith Kumar Uppunda3
1Department of Audiology, All India Institute of Speech and Hearing, A recognized Research Centre of University of Mysore, India.
None:
Misophonia is characterized by intense emotional responses to specific sounds, yet its neurophysiological basis remains unclear. This study investigated auditory cortical processing using multichannel auditory late latency responses (ALLR). ALLR recordings were obtained from 30 participants (15 with misophonia and 15 controls). Latencies and amplitudes of the P1-N1-P2 peaks were analyzed at Fz, Cz, and Pz, along with scalp topography. Results showed significantly earlier latencies and reduced N1 amplitudes in the misophonia group across all sites (Fz, Cz, and Pz), indicating heightened cortical activity. Topographical analysis revealed distinct scalp patterns: the misophonia group showed centro-parietal distributions, contrasting with the fronto-central patterns exhibited in controls. These findings suggest altered early-auditory processing and atypical cortical activation in individuals with misophonia, supporting its neurophysiological basis. The reduced N1 amplitude may represent a neurophysiological biomarker, while multichannel ALLR could serve as an objective index for diagnosis and treatment monitoring in future clinical applications.
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