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POLYCYSTIC OVARY SYNDROME: ORIGINS AND IMPLICATIONS: PCOS in adolescents: ontogeny of neuroendocrine and metabolic
Hala Tfayli1, Silva Arslanian2,3, Selma Feldman Witchel3
1Department of Pediatrics and Adolescent Medicine, Division of Pediatric Endocrinology, American University of Beirut, Beirut, Lebanon.
In Brief:
Early clinical manifestations of PCOS may begin during puberty. This paper reviews the initial characteristics of PCOS in the adolescent girl.
Abstract:
Polycystic ovary syndrome (PCOS) is a heterogeneous multi-factorial familial disorder characterized by androgen excess, irregular menses, and chronic anovulation. The key features, hyperandrogenism, insulin resistance, and hyperinsulinemia, can be identified in peripubertal girls. From a pediatric/adolescent point of view, the ability to identify girls with PCOS or those 'at-risk for PCOS' is crucial to target educational and medical resources to promote healthy lifestyle interventions for these girls to minimize progression to PCOS and curtail the associated comorbidities.
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