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Multifunctional SFPQ Protein: Role in Double-Strand DNA Break Repair
Yulia Yu Agapkina1,2, Mariia O Silkina1, Tatiana F Kikhai1
1Faculty of Chemistry, Lomonosov Moscow State University, Moscow, 119991, Russia.
Biochemistry. Biokhimiia
|November 2, 2025
Summary
Splicing Factor Proline and Glutamine rich (SFPQ) protein and its partner NONO are vital for DNA repair. This review details their roles in fixing double-strand DNA breaks (DSBs).
Area of Science:
- Molecular Biology
- Cell Biology
- Genetics
Background:
- Splicing Factor Proline and Glutamine rich (SFPQ) is a nuclear protein involved in multiple cellular functions.
- SFPQ forms a heterodimer with Non-POU domain-containing octamer-binding protein (NONO), a key component of paraspeckles.
- SFPQ plays a role in DNA double-strand break (DSB) repair, though its precise mechanism is unclear.
Purpose of the Study:
- To review and consolidate current knowledge on the function of SFPQ and its complex with NONO in DSB repair.
Main Methods:
- Literature review of existing studies on SFPQ, NONO, and DNA repair mechanisms.
Main Results:
- SFPQ is essential for cell viability and participates in various cellular processes.
- The SFPQ-NONO heterodimer is crucial for paraspeckle formation.
- Evidence suggests SFPQ involvement in DSB repair pathways.
Conclusions:
- Further research is needed to fully elucidate the mechanism of SFPQ in DSB repair.
- Understanding SFPQ's role in DNA repair could have implications for cancer therapy and genetic stability.
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