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Updated: May 6, 2026

A Preclinical Mouse Model of Osteosarcoma to Define the Extracellular Vesicle-mediated Communication Between Tumor and Mesenchymal Stem Cells

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Preoperative Multi-model Images-based Radiomics Model for Distinguishing Spinal Osteosarcoma and Chondrosarcoma.

Chenxi Wang¹, Yuan Yuan¹, Kai Ye¹

¹Department of Radiology, Peking University Third Hospital, 49 North Garden Road, Haidian District, Beijing, 100191, People's Republic of China.

Current Medical Imaging

|November 2, 2025

Summary

An MRI-based radiomics model accurately distinguishes spinal osteosarcoma from chondrosarcoma, outperforming CT scans and radiologists. This tool aids in preoperative diagnosis for timely treatment decisions.

Keywords:

Chondrosarcoma Computed tomography Differential diagnosis Magnetic resonance imaging.Osteosarcoma Radiomics

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Machine Learning Algorithms for Early Detection of Bone Metastases in an Experimental Rat Model

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Area of Science:

Oncologic Imaging
Radiomics and Machine Learning
Spinal Tumors

Background:

Distinguishing spinal osteosarcoma from chondrosarcoma is challenging.
Accurate preoperative diagnosis is crucial for effective treatment planning.

Purpose of the Study:

To develop and validate a radiomics fusion model using CT and MRI for differentiating spinal osteosarcoma and chondrosarcoma.
To compare the diagnostic performance of models based on different imaging modalities.

Main Methods:

Retrospective analysis of 63 patients with spinal osteosarcoma or chondrosarcoma.
Extraction of radiomics features from CT and MRI sequences.
Development and evaluation of eight machine learning models, including CT, MR, combined CT-MR, and clinico-CT-MR.

Main Results:

The MRI-based radiomics model achieved the highest diagnostic performance (AUC=0.963), significantly outperforming CT-based models and radiologists.
Combined CT-MR and clinico-CT-MR models did not significantly improve diagnostic accuracy over the MR model.
The MR model demonstrated excellent calibration and clinical utility.

Conclusions:

MRI-based radiomics is highly effective for preoperative discrimination between spinal osteosarcoma and chondrosarcoma.
This clinically practical tool can support preoperative diagnosis using routine MRI.
Facilitates timely and informed treatment decisions for spinal tumors.