Povidone-iodine for transrectal prostate biopsy
Onuralp Ergun1,2, Evelyn W Arden3, Bowen Yao1
1Department of Urology, University of Minnesota, Minneapolis, Minnesota, USA.
The Cochrane Database of Systematic Reviews
|November 3, 2025
Summary
This review protocol examines the impact of rectal cleansing using povidone-iodine (PVP-I) compared to no cleansing in individuals undergoing transrectal ultrasound-guided prostate biopsy (TRUSP). The goal is to evaluate the effectiveness of PVP-I rectal cleansing.
Area of Science:
- Medical research methodology
- Surgical intervention protocols
- Infection control in healthcare settings
Background:
- Transrectal ultrasound-guided prostate biopsy (TRUSP) is a common urological procedure.
- Rectal cleansing is sometimes employed to reduce the risk of infectious complications.
- Povidone-iodine (PVP-I) is an antiseptic agent with broad-spectrum antimicrobial activity.
Purpose of the Study:
- To systematically review and synthesize evidence on the effects of rectal cleansing with povidone-iodine (PVP-I) versus no cleansing in patients undergoing TRUSP.
- To assess the impact of PVP-I rectal cleansing on infectious complications and other outcomes following TRUSP.
Main Methods:
- This is a protocol for a Cochrane Review.
- The review will adhere to Cochrane methodology for intervention reviews.
- Systematic search of relevant databases will be conducted to identify eligible studies.
Main Results:
- This section will report the findings of the systematic review once studies are identified and analyzed.
- Results will focus on comparing outcomes between the PVP-I cleansing group and the no cleansing control group.
Conclusions:
- The conclusions will be drawn based on the synthesized evidence regarding the efficacy and safety of PVP-I rectal cleansing prior to TRUSP.
- This review aims to inform clinical practice guidelines for TRUSP procedures.
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