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First Case of a Biochemically Normal Intrathyroidal Parathyroid Carcinoma: Case Report and Literature Review
Haley G Jo1, Jeffrey G Moore2, Anjana V Harnoor2
1Department of Molecular and Cell Biology University of California San Diego California USA.
Clinical Case Reports
|November 3, 2025
Summary
This study details the first reported case of biochemically normal intrathyroidal parathyroid carcinoma (PC), a rare endocrine malignancy. It highlights the unusual presentation and location of this aggressive cancer.
Area of Science:
- Endocrinology
- Oncology
- Pathology
Background:
- Parathyroid carcinoma (PC) is a rare and aggressive endocrine malignancy.
- Intrathyroidal presentation of PC is exceptionally rare.
Purpose of the Study:
- To report the first case of a biochemically normal intrathyroidal parathyroid carcinoma.
- To review the existing literature on this rare clinical entity.
Main Methods:
- Case report of a patient with intrathyroidal parathyroid carcinoma.
- Literature review of intrathyroidal parathyroid carcinoma cases.
Main Results:
- The study presents the first documented case of biochemically normal intrathyroidal parathyroid carcinoma.
- Literature review confirms the rarity of this presentation.
Conclusions:
- Intrathyroidal parathyroid carcinoma, even when biochemically normal, represents a rare and aggressive malignancy.
- Further research and awareness are needed for early diagnosis and management of this rare entity.
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