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Splenectomy and hepatocellular carcinoma: Cause or confounder?

Seoung Hoon Kim1

  • 1Organ Transplantation Center, National Cancer Center, Goyang 10408, South Korea. kshlj@hanmail.net.

World Journal of Hepatology
|November 3, 2025
PubMed
Summary

Splenectomy is not a direct cause of hepatocellular carcinoma (HCC). The primary risk for HCC in cirrhotic patients stems from underlying liver disease, not spleen removal. Further research is needed.

Keywords:
Hepatocellular carcinomaHypersplenismLiver cirrhosisPortal hypertensionSplenectomy

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