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Retroperitoneal Lipomatosis
Floriane Bootsma1, Adelard De Backer1
1Vrije Universiteit Brussel (VUB), Universitair Ziekenhuis Brussel (UZ Brussel), Department of Radiology, Laarbeeklaan 101, 1090 Brussels, Belgium.
Journal of the Belgian Society of Radiology
|November 3, 2025
Summary
Retroperitoneal lipomatosis is a benign idiopathic condition causing gradual fat buildup in the retroperitoneum. This condition presents as symmetrical lesions without areas of increased density on imaging.
Area of Science:
- Medical Imaging
- Pathology
- Radiology
Background:
- Retroperitoneal lipomatosis is a rare condition characterized by excessive fat accumulation in the retroperitoneal space.
- The etiology of this idiopathic process remains largely unknown.
- It is typically a benign condition with a slow, progressive course.
Purpose of the Study:
- To describe the key imaging features of retroperitoneal lipomatosis.
- To differentiate it from other retroperitoneal masses.
- To highlight its benign nature.
Main Methods:
- Review of imaging findings (CT, MRI) in patients diagnosed with retroperitoneal lipomatosis.
- Correlation of imaging characteristics with pathological findings where available.
- Analysis of lesion characteristics such as size, density, homogeneity, and symmetry.
Main Results:
- Retroperitoneal lipomatosis presents as a diffuse, symmetrical increase in retroperitoneal fat.
- Lesions are typically homogeneous and isodense or slightly hypodense compared to subcutaneous fat on CT.
- No enhancing components or areas of increased density are usually observed, aiding in differentiation from liposarcoma.
Conclusions:
- Retroperitoneal lipomatosis is a benign condition with characteristic imaging findings.
- Its symmetrical, homogeneous nature and lack of increased density are key diagnostic features.
- Radiological assessment can reliably identify this entity, avoiding unnecessary invasive procedures.

