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Related Concept Videos

Rheumatic Heart Disease I: Introduction01:23

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Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
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The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
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Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
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Related Experiment Video

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Author Spotlight: Enhancing Rheumatoid Arthritis Research Through HR-pQCT Imaging Analysis
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Typical CT Pattern in Rheumatoid Arthritis: Exuberant Honeycombing.

Cédric Descatoire1, Pascale Bohy1

  • 1Hôpital Universitaire de Bruxelles (HUB), Belgium.

Journal of the Belgian Society of Radiology
|November 3, 2025
PubMed
Summary

Exuberant honeycombing on chest CT scans is a specific indicator of interstitial lung disease linked to connective tissue disease. This finding helps distinguish it from idiopathic pulmonary fibrosis.

Keywords:
HRCTexuberant honeycombingrheumatoid arthritis

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Area of Science:

  • Pulmonology
  • Radiology
  • Rheumatology

Background:

  • Interstitial lung diseases (ILDs) encompass a diverse group of lung disorders.
  • Connective tissue disease-associated ILD (CTD-ILD) and idiopathic pulmonary fibrosis (IPF) are distinct entities with overlapping imaging features.
  • Accurate differentiation is crucial for prognosis and treatment.

Purpose of the Study:

  • To evaluate the diagnostic significance of exuberant honeycombing on high-resolution computed tomography (HRCT) in differentiating CTD-ILD from IPF.
  • To determine if this specific imaging pattern aids in classifying ILDs with a usual interstitial pneumonia (UIP) pattern.

Main Methods:

  • Retrospective analysis of HRCT scans from patients diagnosed with CTD-ILD and IPF.
  • Radiological assessment focusing on the presence and extent of honeycombing.
  • Comparison of imaging findings between the CTD-ILD and IPF groups.

Main Results:

  • Exuberant honeycombing was identified as a specific characteristic in CTD-ILD cases exhibiting a UIP pattern.
  • The presence of exuberant honeycombing was significantly associated with CTD-ILD.
  • This feature aids in distinguishing CTD-ILD from IPF on HRCT.

Conclusions:

  • Exuberant honeycombing on HRCT is a valuable imaging biomarker for CTD-ILD with a UIP pattern.
  • This finding can assist radiologists and clinicians in differentiating CTD-ILD from IPF.
  • Incorporating this specific sign into diagnostic criteria may improve ILD classification.