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Metal-Free, Photoinduced On-DNA Synthesis of β-Hydroxy Sulfides
Yagong Wang1, Hangke Ma1, Ivan Hu2
1Pharmaron (Ningbo) Technology Development Company, Ltd. No. 800 Bin-Hai 4th Road, Qianwan New Area, Ningbo 315336, China.
Abstract:
We present a metal-free photochemical strategy for the synthesis of on-DNA β-hydroxy sulfides, which are essential pharmacophores with limited access via existing DNA-encoded library (DEL) methodologies. This innovative hydrothiolation features a broad substrate scope with both thiols and olefins. Its operational simplicity and excellent DNA compatibility enable the efficient construction of diverse DELs, significantly expanding the accessible chemical space for drug discovery and providing a new tool for identifying novel therapeutics.
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