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Updated: Jan 12, 2026

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Dual-Co/Ni-Catalyzed Radical Hydroarylation of 1,3-Enynes: Selective Access to Tetrasubstituted Allenes
Qi Meng1, Ting Yin1, Zhimeng Song1
1Jilin Province Key Laboratory of Organic Functional Molecular Design & Synthesis, Department of Chemistry, Northeast Normal University, Changchun 130024, China.
Abstract:
Metal hydride hydrogen atom transfer (MHAT) has emerged as a powerful strategy for alkene hydrofunctionalization, offering exceptional control over regio- and chemoselectivity. However, conventional MHAT reactions with 1,3-enynes remain limited to the 1,2-addition pathway. Herein, we report a regioselective 1,4-hydroarylation of 1,3-enynes with various aryl halides enabled by dual cobalt and nickel catalysis. This transformation proceeds through cobalt(III)-H-mediated HAT to the 1,3-enynes, followed by nickel-catalyzed cross-coupling with aryl halides, delivering a wide range of tetrasubstituted allenes in good to excellent yields. This work expands the scope of Co(III)H-mediated radical hydrofunctionalization reactions and offers a modular strategy for constructing valuable, highly substituted allene building blocks.
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