Related Experiment Video

Updated: May 6, 2026

Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy
05:52

Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy

Published on: August 19, 2021

13.7K

SEOM-GEICAM-SOLTI clinical guidelines in advanced breast cancer (UPDATE 2025)

Jose Angel Garcia-Saenz1, Isabel Blancas Lopez-Barajas2, Isabel Echavarria3

  • 1Medical Oncology Department, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria San Carlos (IdISSC), CIBERONC, Madrid, Spain. jgsaenz@salud.madrid.org.

Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
|November 3, 2025
PubMed

Insights

Advanced breast cancer presents treatment challenges due to genomic changes. These 2025 guidelines offer updated evidence and therapies to improve quality of life and survival for patients with advanced breast cancer.

Area of Science:

  • Oncology
  • Genomics
  • Medical Treatment

Background:

  • Advanced breast cancer is characterized by dynamic genomic alterations.
  • These genomic changes contribute to treatment resistance.
  • Effective management requires understanding the disease's natural history.

Purpose of the Study:

  • To summarize current evidence for advanced breast cancer management.
  • To outline available therapies for medical treatment.
  • To provide updated guidelines for 2025.

Main Methods:

  • Review of current scientific evidence.
  • Analysis of available therapeutic options.
  • Synthesis of data for guideline development.

Main Results:

  • Identification of key genomic drivers in treatment resistance.
  • Evaluation of treatment efficacy and sequencing strategies.
  • Compilation of updated therapeutic recommendations.

Conclusions:

  • Personalized treatment sequencing is crucial for advanced breast cancer.
  • Continuous updates in evidence are necessary for optimal patient outcomes.
  • These guidelines aim to enhance patient survival and quality of life.
Keywords:
Advanced breast cancerAnti-HER2 therapyEndocrine therapyGuidelinesMetastatic breast cancer

More Related Videos

Single-Port Robotic-assisted Transaxillary Breast-conserving Surgery: A Prospective, Single-arm, Non-randomized Phase IIa Clinical Trial03:07

Single-Port Robotic-assisted Transaxillary Breast-conserving Surgery: A Prospective, Single-arm, Non-randomized Phase IIa Clinical Trial

Published on: August 19, 2025

1.6K
Laparoscopic Radical Gastrectomy for Remnant Gastric Cancer05:30

Laparoscopic Radical Gastrectomy for Remnant Gastric Cancer

Published on: October 31, 2025

464

Related Concept Videos

Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
8.6K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.1K
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
2.7K
Standards of Care I01:22

Standards of Care I

Federal statutes profoundly impact nursing practice, providing critical guidelines to ensure patient care is equitable, accessible, and of the highest quality. The following laws address distinct aspects of healthcare provision and patient rights:
1.2K
Standards of Care II01:19

Standards of Care II

Nurses bear specific legal responsibilities under several federal statutes, including:
1.1K
Cancer Survival Analysis01:21

Cancer Survival Analysis

Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
870