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Related Concept Videos

Cancer Survival Analysis01:21

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Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
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Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
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A Knowledge Graph Approach to Elucidate the Role of Organellar Pathways in Disease via Biomedical Reports
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Leveraging oncology clinical case report data through the Cancer Knowledgebase (CKB).

Rewatee H Gokhale1, Cara M Statz1, Taofei Yin1

  • 1Genomenon Inc, Ann Arbor, MI, USA.

Personalized Medicine
|November 3, 2025
PubMed
Summary
This summary is machine-generated.

Clinical case reports offer valuable oncology data. The Cancer Knowledgebase (CKB) organizes this data, enabling healthcare providers to identify targeted therapies for rare cancers and complex patient cases.

Keywords:
Genomicscase reportsdatabaseknowledgebaseoncologyprecision medicine

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Area of Science:

  • Oncology
  • Bioinformatics
  • Clinical Data Mining

Background:

  • Clinical case reports in oncology contain rich patient data linking molecular alterations, tumor types, and treatment responses.
  • Systematic organization of this clinical evidence is lacking, hindering its use in practice.

Purpose of the Study:

  • To demonstrate the utility of the Cancer Knowledgebase (CKB) for interpreting oncology case report data.
  • To showcase CKB's capability in organizing clinical evidence for healthcare providers.

Main Methods:

  • Analysis of 5527 manually curated case reports within the CKB.
  • Extraction of data on molecular profiles, therapies, indications, and patient responses.

Main Results:

  • Efficacy evidence spans over 500 genes, 2800 molecular profiles, and 300 tumor types, including rare and pediatric cancers.
  • Each case report is annotated with molecular profile, therapy, indication, and response.

Conclusions:

  • CKB is a valuable resource for identifying treatment options for rare cancers and oncogenic variants.
  • CKB aids in selecting therapies for patients with multiple treatment options or resistance to first-line therapy.