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Metastasizing ameloblastoma: a case report.

Rohan Shetty1, Rohan Thomas Mathew2, Rohit Singh1

  • 1Department of Surgical Oncology, Zulekha Yenepoya Institute of Oncology, Yenepoya (Deemed to Be University), Mangalore, Karnataka, 575018, India.

Journal of Medical Case Reports
|November 4, 2025
PubMed
Summary
This summary is machine-generated.

Metastasizing ameloblastoma, a rare benign tumor, can recur locally and metastasize to the lungs. Increased suspicion is vital for recurrent cases, as pulmonary metastasis may be indolent and easily missed.

Keywords:
AmeloblastomaMetastasizing ameloblastomaPulmonary metastasis

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Area of Science:

  • Oncology
  • Pathology
  • Oral and Maxillofacial Surgery

Background:

  • Metastasizing ameloblastoma is a rare entity classified by the World Health Organization, characterized by metastasis despite a benign nature.
  • Incidence is estimated at 2% of ameloblastoma cases, though potentially lower due to underdiagnosis.

Purpose of the Study:

  • To report a rare case of metastasizing ameloblastoma with pulmonary metastasis.
  • To highlight the importance of vigilance in diagnosing pulmonary metastasis in patients with recurrent ameloblastoma.

Main Methods:

  • Case presentation of a 30-year-old woman with a history of recurrent ameloblastoma.
  • Diagnostic evaluation including imaging (CT scan) and bronchoscopy-guided biopsy.
  • Multidisciplinary tumor board discussion and treatment decision.

Main Results:

  • The patient presented with recurrent ameloblastoma, followed by pulmonary nodules and a parahilar lesion.
  • Biopsy confirmed metastatic ameloblastoma.
  • Despite refusing further treatment, the patient reported symptomatic improvement.

Conclusions:

  • Ameloblastoma is locally aggressive and rarely metastasizes.
  • Pulmonary metastasis from ameloblastoma can be indolent and easily overlooked.
  • Higher suspicion is warranted in patients with a history of recurrent ameloblastoma.