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Related Experiment Video

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Implementation of a Reference Interferometer for Nanodetection
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Compact and bench-top common-path interferometric biosensor utilizing guided mode resonance phase enhancement.

Neethu Baburaj, Pankaj K Sahoo, Debashree Kar

    Optics Letters
    |November 4, 2025
    PubMed
    Summary

    This study presents a novel, sensitive optical detection system using guided mode resonance and a Fresnel biprism. The compact, low-cost device accurately detects low concentrations of biomarkers like bovine serum albumin (BSA).

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    Area of Science:

    • Biomedical Optics
    • Biosensing Technology
    • Optical Metrology

    Background:

    • Early disease detection relies on sensitive biomarker quantification.
    • Serum albumin is a key biomarker for various diseases, indicating progression and treatment efficacy.
    • Existing detection methods often lack sensitivity, speed, or non-invasiveness.

    Purpose of the Study:

    • To develop a highly sensitive, reliable, and non-invasive optical detection system.
    • To utilize guided mode resonance (GMR) for enhanced phase sensitivity.
    • To demonstrate the system's capability in detecting low concentrations of biomarkers.

    Main Methods:

    • A common-path phase-detection system was designed using a Fresnel biprism and GMR.
    • The system integrates a compact, bench-top setup with low-cost components.
    • Mechanical vibrations were mitigated through a common-path configuration.

    Main Results:

    • The GMR-based instrument demonstrated high stability and sensitivity.
    • Bovine serum albumin (BSA) was detected at concentrations as low as 1 pg/mL.
    • The system offers a low limit of detection (LOD) compared to other methods.

    Conclusions:

    • The developed optical phase detection system offers a sensitive and reliable method for biomarker quantification.
    • The combination of Fresnel biprism and GMR provides enhanced phase sensitivity.
    • This technology has potential for early disease diagnosis and monitoring treatment efficacy.