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Published on: April 23, 2019
Synergistic PEDOT:SBCD Electrochemical Platform for Simultaneous Detection of Multiple Metabolic Biomarkers in Human
Yu Zhang1, Jia Guo1, Zuhang Ding1
1Tianjin Key Laboratory of Multiplexed Identification for Port Hazardous Chemicals, College of Chemical Engineering and Materials Science, Tianjin University of Science Technology, Tianjin 300457, P.R. China.
Abstract:
In this work, an electrochemical platform based on poly(3,4-ethylenedioxythiophene) doped with sulfonated β-cyclodextrin (PEDOT:SBCD) was developed for the simultaneous detection of ascorbic acid (AA), dopamine (DA), uric acid (UA), l-tyrosine (l-Tyr), and nitrite (NO2-). The PEDOT:SBCD composite was synthesized via oxidative polymerization and characterized in detail. Afterward, under optimal conditions, the linear ranges were 5-4000 μM for AA, 0.1-250 μM for DA, 0.1-250 μM for UA, 5-1500 μM for l-Tyr, and 5-1000 μM for NO2-, and the detection limits were 1.581 μM (AA), 0.061 μM (DA), 0.122 μM (UA), 0.629 μM (l-Tyr), and 0.510 μM (NO2-), respectively. Notably, the platform achieved direct detection in real urine samples with minimal pretreatment, demonstrating excellent anti-interference capability and long-term stability. Additionally, it consistently detected target analytes in actual urine samples from volunteers of varying genders and age. This work provides a potential robust electrochemical platform for personalized and preventive healthcare.
