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Updated: Jan 12, 2026
Differentiated Mouse Adipocytes in Primary Culture: A Model of Insulin Resistance
Published on: February 17, 2023
Mediating Role of Insulin Resistance in the Association Between Body Composition and Hypertension
Qingfang Deng1, Hao Kang1, Yu Cao1
1School of Public Health, Anhui Medical University, No 81 Meishan Road, Hefei, 230032, Anhui, China.
Introduction:
Hypertension, a major cardiovascular risk, is affected by body composition and metabolism.
Aim:
We assessed the associations of body composition with hypertension and the mediating role of insulin resistance (IR).
Methods:
In Hefei Hongsifang Company, 743 employees aged 40-60 were recruited consecutively. Logistic regression was used to assess the association between body composition and hypertension risk. Mediation analysis was conducted to explore the mediating role of IR between body composition and hypertension risk.
Results:
Individuals with higher body fat percentage (BF%) (OR = 2.44, 95% CI 1.64-3.65, P < 0.001) and Visceral adiposity index (VAI) (OR = 2.22, 95% CI 1.39-3.55, P < 0.001) had significantly higher odds of hypertension. Conversely, higher levels of skeletal muscle mass percentage (SMM%) (OR = 0.35, 95% CI 0.21-0.56, P < 0.001), total body water percentage (TBW%) (OR = 0.36, 95% CI 0.23-0.59, P < 0.001), and bone mineral content percentage (BMC%) (OR = 0.34, 95% CI 0.21-0.54, P < 0.001) were all linked to lower odds of hypertension. IR significantly mediated the associations between body composition and hypertension risk. The mediation proportions were as follows: 29.4% for BF%, 61.5% for VAI, 33.7% for SMM%, 34.9% for TBW%, and 31.4% for BMC%.
Conclusion:
Our study demonstrated that, in middle-aged individuals, lower BF% and VAI, as well as higher SMM%, TBW%, and BMC%, were independently associated with a reduced risk of hypertension. IR partially mediated the associations between body composition and hypertension.
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