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Multilevel Microdissection and Functional-Structural Profiling of Human Renal Arterial Branches
Published on: September 5, 2025
Global research trends in renal anemia: a multidimensional bibliometric study
Yuanchen Niu1,2, Yufang Wang3, Changhong Huo3
1Key Laboratory of Molecular Target & Clinical Pharmacology and the State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences & the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
This study maps global research on renal anemia, revealing a shift from erythropoietin to hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHIs). Emerging research focuses on HIF-PHI translation and novel therapies for chronic kidney disease complications.
Area of Science:
- Nephrology
- Hematology
- Bibliometrics
Background:
- Renal anemia is a significant complication of chronic kidney disease (CKD), increasing cardiovascular risk and mortality.
- Despite its impact, comprehensive bibliometric analyses of global research trends in renal anemia are lacking.
Purpose of the Study:
- To conduct a bibliometric analysis of global research on renal anemia.
- To identify knowledge gaps, research hotspots, and evolving therapeutic strategies.
Main Methods:
- Publications on renal anemia (1965-2024) were retrieved from Web of Science Core Collection.
- Data analysis and visualization were performed using VOSviewer, CiteSpace, Pajek, and Origin.
Main Results:
- 1,664 publications from 72 countries were analyzed, with leading contributions from Japan, the US, and China.
- Research has evolved from erythropoiesis-stimulating agents to hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHIs).
- Current hotspots include HIF-PHI clinical translation and emerging therapies targeting SGLT2, hepcidin, FGF23, gut microbiota, zinc, and stem cells.
Conclusions:
- The field of renal anemia research has transitioned towards HIF-PHI-centered physiological modulation.
- Future therapeutic avenues are likely to involve SGLT2 inhibitors, hepcidin antagonists, FGF23 modulation, gut microbiota regulation, zinc, and stem cell therapies.
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